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Title   유방암에서 ICF ( Ifosfamide , Carbopatin , Etoposide ) 고용량 화학요법과 자가조혈모세포이식술 ( High Dose Chemotherapy with Ifosfamide , Carboplatin , and Etoposide Followed by Autologous Stem Cell Transplantation in Breast Cancer )
Publicationinfo   2000 Jan; 032(06): 1059-1067.
Key_word   High dose chemotherapy, Autologous stem cell transplantation, Breast neoplasm
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Abstract   Purpose: To establish the feasibility of high dose ifosfamide, carboplatin, and etoposide (ICE) chemotherapy followed by autologous stem cell transplantation (ASCT) in patients with high-risk or metastatic breast cancer. Materials and Methods: High-risk breast cancer is defined as 10 or more involved axillary lymph nodes (n=3) or stage III (n=2). Patients with metastatic cancer have relapsed diseases after curative resection (n=10) or initially metastatic lesion (n=l), Colony stimulating factor with either cyclophosphamide or combination chemotherapy was administered to mobilize the stem cells. High dose chemotherapy consisted of ifosfamide 16 g/m, carboplatin 1.8 g/m, and etoposide 0.75 g/m (dose I) and later modified to ifosfamide 12 g/m, carboplatin 1.35 g/m, and etoposide 1.2 g/m (dose II). Results: The median duration of grunulocyte nadir (<500/ μL) was 11 (10~17) days and platelet transfusion dependency (<20,000/pL) was 11 (7-53) days in 14 patients who achieved engraftment. One out of 5 patients with high-risk breast cancer relapsed after high dose therapy. Two patients remain disease-free at 18th and 40th months. Two among the 4 patients treated with dose I died due to treatment-related complications. The responses of metastatic diseases to ICE chemotherapy were 1 continuing CR, 1 CR, 1 PR, 4 SD and 3 PD in 10 evaluable patients. Conclusion: High dose ICE chemotherapy, especially dose II and ASCT were feasible in high-risk or metastatic breast cancer.
저 자   박영석(Young Seok Park),방영주(Yung Jue Bang),김노경(Noe Kyeong Kim),방수미(Soo Mee Bang),이세훈(Se Hoon Lee),조은경(Eun Kyung Cho),이정해(Jung Ae Lee),신동복(Dong Bok Shin),이재훈(Jae Hoon Lee),박선양(SeonYangPark),김병국(Byoung Kook Kim)